Effects of Oxidative Stress on Telomeres in the Ovaries Telomeres and Ovarian Aging Telomeres, the dynamic nucleoproteinDNA structures present at both ends of each chromosome, are responsible for maintaining genome integrity and chromosome stability (Zhang et al., 2018)
Fortunately, the new wave of weight loss drugs including semaglutide (Ozempic, Wegovy) and tirzepatide (Mounjaro, Zepbound) may help some women with unwanted menopause weight gain
Useful oxidative-damage markers may include urinary 8-OHdG , which reflects oxidative DNA damage, and lipid peroxides , which reflect oxidative damage to fats and cell membranes
Note: Compounded semaglutide is not FDA-approved
When used together, there may be an additive effect on heart rate , which could be clinically significant in patients with pre-existing cardiovascular conditions, including hypertension, arrhythmias, or coronary artery disease